Implementation and population of a high-quality database of transcription 3’end sequences to support Gene Logic’s proprietary READS technology Developing programs that use the database for quality control to help optimize laboratory procedures Development and integration of a system for automating the analysis of READS gel images: lane/band detection; lane calibration (restriction fragment size); lane alignment; visual side-by-side comparison of arbitrary, user selected lanes; identification of genes corresponding to user selected bands through lane comparisons and/or band position predictions computed from database information, etc. Prediction of READS gel image patterns through DNA fragment size computation from mRNA 3'end sequence database and expression level estimates.